CCNE1 AMPLIFICATION Detail (hg19) (CCNE1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr19:30,302,805-30,315,215 |
| hg38 | chr19:29,811,898-29,824,308 View the variant detail on this assembly version. |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| estrogen-receptor positive breast cancer | Palbociclib | D |
Predictive
|
Supports
|
Resistance |
N/A
|
3 | 27020857 | Detail |
| ovarian serous cystadenocarcinoma | Dinaciclib,Akt Inhibitor MK2206 | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 27663592 | Detail |
| ovarian carcinoma | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 4 | 20336784 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Preclinical study in breast cancer cell lines treated with CDK4/6 inhibitor palbociclib. Cell lines ... | CIViC Evidence | Detail |
| A high throughput compound screen identified synergistic combinations in CCNE1 amplified high grade ... | CIViC Evidence | Detail |
| In a retrospective study of 88 ovarian carcinomas, 18 had amplification of CCNE1. Those with amplifi... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- CCNE1
- Genome
- hg19
- Position
- chr19:30,302,805-30,315,215
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- AMPLIFICATION
- Transcript 1 (CIViC Variant)
- ENST00000262643.3
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/187
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